The search for novel anti-infectives is one of the most important challenges in natural product research of this century, as diseases caused by bacteria, viruses and fungi are influencing the human society all over the world. The old resources are exploited and only the combination of the usage of novel ones like the biological resources in Indonesia, together with high sophisticated biological assays and screening technologies can be successful in the future. To the organisms which will be used belong marine and terrestrial microorganisms from the groups of the myxobacteria as well as actinobacteria, plants and marine organisms like sponges and cucumbers. The extracts of these organisms will be analyzed by different biological assays as well as chemical dereplication with different techniques which are established by the partner groups. The active microorganisms will be cultivated in a larger scale fermentation for the isolation of the compounds. These compounds as well as the ones that are extracted from plant and marine organisms will then be structure elucidated.
Therefore, it is the aim of this coordinated, interdisciplinary project to exploit the vast diversity of natural compounds with diverse biological provides by natural sources. Within this project, this unique resource will be systematically made accessible to screening campaigns involving human pathogenic viruses, bacteria and fungi. Ultimately, this project will identify novel anti-infective molecules and will establish a coordinated operation structure to access natural resources for development of anti-infectives for treatment of human diseases.
Dr. Joachim Wink, Microbial Strain Collection, Metabolite Producing Microorganisms, Helmholtz Centre for Infection Research (HZI), Braunschweig
Dr. Enge Sudarman, Microbial Drugs, Helmoltz Centre for Infection Research (HZI), Braunschweig
Dr. Kathrin I. Mohr, New Bacterial Secondary Metabolites, New Myxcobacterial Strains, Helmholtz Centre for Infection Research (HZI), Braunschweig
Dr. Eike Steinmann, Virology, Microbiology and Molecular Biology, Center for Experimental and Clinical Infection Research (TWINCORE), Hannnover
Prof. Dr. Thomas Pietschmann, Experimental Virology, Center for Experimental and Clinical Infection Research (TWINCORE), Hannover
Prof. Dr. Peter Schupp, Environmental Biochemistry, Carl-von-Ossietzky Universität Oldenburg, ICBM-Terramare, Wilhelmshaven
Dr. Andreas Kunzmann, Ecology, WG Ecophysiology, Leibniz Center for Tropical Marine Ecology (ZMT), Bremen
Dr. Tjandrawati Mozef, Biochemistry, Research Centre for Chemistry, Institute of Science (LIPI), Bandung
Prof. Dr. Dwi Andreas Santosa, Soil Biotechnology and Molecular Genetics, Graduate School, Bogor Agricultural University (IPB)
Dr. Heni Rachmawati, Pharmaceutical Solid Formulation, Nanotechnology-based Formulation, Drug Delivery and Drucg Targeting, School of Pharmacy, Bandung Institute of Technology (ITB)
Dr. Muhammad Insanu, Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology (ITB)
Dr. Zainal Arifin, Ecotoxicology, Biodiversity and Conservation, LIPI Research Center for Oceanography, Jakarta
Dr. Ario Damar, Coastal Aquatic Ecology, Eutrophication, Primary Production Planton, Center for Coastal and Marine Resources Studies, Bogor Agricultural University (IPB)
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